NEUROFIBRILLARY TANGLES IN DEMENTIA-PUGILISTICA ARE UBIQUITINATED

被引：56
作者：
DALE, GE
LEIGH, PN
LUTHERT, P
ANDERTON, BH
ROBERTS, GW
机构：
[1] ST MARYS HOSP, SCH MED, DEPT ANAT & CELL BIOL, PRAED ST, LONDON W2 1PG, ENGLAND
[2] ST GEORGE HOSP, SCH MED, DEPT IMMUNOL, LONDON, ENGLAND
[3] INST PSYCHIAT, COLL NEUROL, LONDON SE5 8AF, ENGLAND
[4] INST PSYCHIAT, DEPT NEUROPATHOL, LONDON SE5 8AF, ENGLAND
[5] INST PSYCHIAT, DEPT NEUROSCI, LONDON SE5 8AF, ENGLAND
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 02期
关键词：
D O I：
10.1136/jnnp.54.2.116
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Ubiquitin, a protein thought to be involved in the ATP-dependent nonlysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.
引用
收藏
页码：116 / 118
页数：3
相关论文
共 20 条
[1]   HETEROGENEITY OF UBIQUITIN IMMUNOREACTIVITY IN NEUROFIBRILLARY TANGLES OF ALZHEIMERS-DISEASE [J].
BRION, JP ;
POWER, D ;
HUE, D ;
COUCK, AM ;
ANDERTON, BH ;
FLAMENTDURAND, J .
NEUROCHEMISTRY INTERNATIONAL, 1989, 14 (02) :121-128
[2]   UBIQUITIN PROTEIN CONJUGATES IN ALZHEIMERS LESIONS [J].
COLE, GM ;
TIMIRAS, PS .
NEUROSCIENCE LETTERS, 1987, 79 (1-2) :207-212
[3]   AFTERMATH OF BOXING [J].
CORSELLIS, JA ;
BRUTON, CJ ;
FREEMANB.D .
PSYCHOLOGICAL MEDICINE, 1973, 3 (03) :270-303
[4]   NEUROLOGICAL SEQUELAE OF BOXING [J].
GUTERMAN, A ;
SMITH, RW .
SPORTS MEDICINE, 1987, 4 (03) :194-210
[5]   18Q-SYNDROME - NEUROFIBRILLARY TANGLES WITHOUT NEURITIC PLAQUES [J].
HALLIDAY, WC ;
CHUDLEY, AE .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (03) :308-308
[6]   ALZHEIMERS-DISEASE - A STUDY OF EPIDEMIOLOGICAL ASPECTS [J].
HEYMAN, A ;
WILKINSON, WE ;
STAFFORD, JA ;
HELMS, MJ ;
SIGMON, AH ;
WEINBERG, T .
ANNALS OF NEUROLOGY, 1984, 15 (04) :335-341
[7]  
KAHN J, 1985, NEW ENGL J MED, V313, P520
[8]   LEWY BODY-LIKE HYALINE INCLUSIONS IN SPORADIC MOTOR NEURON DISEASE ARE UBIQUITINATED [J].
KATO, T ;
KATAGIRI, T ;
HIRANO, A ;
KAWANAMI, T ;
SASAKI, H .
ACTA NEUROPATHOLOGICA, 1989, 77 (04) :391-396
[9]   LEWY BODIES ARE UBIQUITINATED - A LIGHT AND ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMICAL STUDY [J].
KUZUHARA, S ;
MORI, H ;
IZUMIYAMA, N ;
YOSHIMURA, M ;
IHARA, Y .
ACTA NEUROPATHOLOGICA, 1988, 75 (04) :345-353
[10]   UBIQUITIN DEPOSITS IN ANTERIOR HORN CELLS IN MOTOR NEURON DISEASE [J].
LEIGH, PN ;
ANDERTON, BH ;
DODSON, A ;
GALLO, JM ;
SWASH, M ;
POWER, DM .
NEUROSCIENCE LETTERS, 1988, 93 (2-3) :197-203
12