Embryonic Stem Cells and Induced Pluripotent Stem Cells

被引：1

作者：

Avcilar, Huseyin ^{[1
]}

Saraymen, Berkay ^{[1
]}

Ozturan, Okan Ozgur ^{[2
]}

Koker, Mustafa Yavuz ^{[1
]}

机构：

[1] Erciyes Univ, Fac Med, Dept Immunol, Kayseri, Turkey

[2] Ortadogu Hosp, Dept Plast Surg, Ankara, Turkey

来源：

ASTIM ALLERJI IMMUNOLOJI | 2018年 / 16卷 / 01期

关键词：

Embryonic stem (ES) cell; parthenogenetic embryonic stem (pgES) cell; induced pluripotent stem (IPS) cell;

D O I：

10.21911/aai.22

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Embryonic stem (ES) cells are derived from cells embedded in the inner cell mass of embryonic blastocytes at the preimplantation stage. These cells have self-renewal and pluripotent capacities. Because of these properties, these cells are thought to be useful in the treatment of many degenerative and genetic diseases. Scientists are forced into new research areas as experiments on human embryonic stem cells become harder because of ethics, politics and religious issues and their limitations related to scientific research. Yamanaka et al. were able to produce induced pluripotent stem (IPS) cells by reprogramming human and mice fibroblasts with four transcription factors (Oct 3/4, Sox-2, Klf-4, c-Myc) (OSKM factors) in 2006 and they started a new era. A new field in stem cell research is established as the produced IPS cells have the same functions as embryonic stem cells. A new scientific field in cellular research for in vitro drug experiments has emerged as personal and disease-specific IPS cells can now be produced.

引用

页码：1 / 10

页数：10

共 40 条

[1]

Appasani K, 2011, STEM CELLS BIOL REG, P3, DOI 10.1007/978-1-60761-860-7_1

[2] Technological Overview of iPS Induction from Human Adult Somatic Cells [J].

Bayart, Emilie ;

Cohen-Haguenauer, Odile .

CURRENT GENE THERAPY, 2013, 13 (02) :73-92

[3] Concise Review: Parthenote Stem Cells for Regenerative Medicine: Genetic, Epigenetic, and Developmental Features [J].

Daughtry, Brittany ;

Mitalipov, Shoukhrat .

STEM CELLS TRANSLATIONAL MEDICINE, 2014, 3 (03) :290-298

[4] ESTABLISHMENT IN CULTURE OF PLURIPOTENTIAL CELLS FROM MOUSE EMBRYOS [J].

EVANS, MJ ;

KAUFMAN, MH .

NATURE, 1981, 292 (5819) :154-156

[5] Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome [J].

Fusaki, Noemi ;

Ban, Hiroshi ;

Nishiyama, Akiyo ;

Saeki, Koichi ;

Hasegawa, Mamoru .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2009, 85 (08) :348-362

[6] Methods for making induced pluripotent stem cells: reprogramming a la carte [J].

Gonzalez, Federico ;

Boue, Stephanie ;

Izpisua Belmonte, Juan Carlos .

NATURE REVIEWS GENETICS, 2011, 12 (04) :231-242

[7] SEXUALLY MATURE INDIVIDUALS OF XENOPUS-LAEVIS FROM THE TRANSPLANTATION OF SINGLE SOMATIC NUCLEI [J].

GURDON, JB ;

ELSDALE, TR ;

FISCHBERG, M .

NATURE, 1958, 182 (4627) :64-65

[8] Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin [J].

Hanna, Jacob ;

Wernig, Marius ;

Markoulaki, Styliani ;

Sun, Chiao-Wang ;

Meissner, Alexander ;

Cassady, John P. ;

Beard, Caroline ;

Brambrink, Tobias ;

Wu, Li-Chen ;

Townes, Tim M. ;

Jaenisch, Rudolf .

SCIENCE, 2007, 318 (5858) :1920-1923

[9]

Horii T, 2011, METHODOLOGICAL ADV C, P221

[10] Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds [J].

Hou, Pingping ;

Li, Yanqin ;

Zhang, Xu ;

Liu, Chun ;

Guan, Jingyang ;

Li, Honggang ;

Zhao, Ting ;

Ye, Junqing ;

Yang, Weifeng ;

Liu, Kang ;

Ge, Jian ;

Xu, Jun ;

Zhang, Qiang ;

Zhao, Yang ;

Deng, Hongkui .

SCIENCE, 2013, 341 (6146) :651-654

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