ACUTE-PHASE HIGH-DENSITY-LIPOPROTEIN IN THE RAT DOES NOT CONTAIN SERUM AMYLOID A-PROTEIN

被引：22

作者：

BALTZ, ML ^{[1
]}

ROWE, IF ^{[1
]}

CASPI, D ^{[1
]}

TURNELL, WG ^{[1
]}

PEPYS, MB ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT MED,IMMUNOL MED UNIT,MRC, ACUTE PHASE PROT RES GRP,DU CANE RD, LONDON W12 0HS, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1987年 / 242卷 / 01期

关键词：

D O I：

10.1042/bj2420301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum amyloid A protein (SAA) is an acute-phase apolipoprotein of high-density lipoprotein (HDL). Its N-terminal sequence is identical with that of amyloid A protein (AA), the subunit of AA amyloid fibrils. However, rats do not develop AA amyloidosis, and we report here that neither normal nor acute-phase rat HDL contains a protein corresponding to SAA of other species. mRNA coding for a sequence homologous with the C-terminal but not with the N-terminal part of human SAA is synthesized in greatly increased amounts in acute-phase rat liver. These observations indicate that the failure of rats to develop AA amyloid results from the absence of most of the AA-like part of their SAA-like protein, and that the N-terminal portion of SAA probably contains the lipid-binding sequences.

引用

页码：301 / 303

页数：3

共 30 条

[1] AMYLOID PROTEIN SAA IS AN APOPROTEIN OF MOUSE PLASMA HIGH-DENSITY LIPOPROTEIN [J].