PLASMA-LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH MEDITERRANEAN SPOTTED-FEVER - CLINICAL AND ANALYTICAL CORRELATIONS

被引：15

作者：

ORISTRELL, J ^{[1
]}

AMENGUAL, MJ ^{[1
]}

FONTCREUS, B ^{[1
]}

CASANOVAS, A ^{[1
]}

SEGURAPORTA, F ^{[1
]}

机构：

[1] HOSP SABADELL, PROGRAM INFECT DIS, E-08208 SABADELL, SPAIN

来源：

CLINICAL INFECTIOUS DISEASES | 1994年 / 19卷 / 06期

关键词：

D O I：

10.1093/clinids/19.6.1141

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty consecutive patients with serologically confirmed Mediterranean spotted fever were analyzed for determination of plasma levels of tumor necrosis factor alpha (TNF-alpha) by means of an ELISA. Increased levels of TNF-alpha in plasma were found during the acute phase of the disease (52.3 +/- 49.8 pg/mL) compared to levels in the convalescent phase (9.0 +/- 9.3 pg/mL; P <.001) or in healthy controls (6.5 +/- 3.2 pg/mL; P <.001). Plasma TNF-alpha levels were significantly higher in patients with severe Mediterranean spotted fever. Levels of TNF-alpha correlated significantly with serum levels of C-reactive protein and triglycerides and inversely with serum levels of sodium.

引用

页码：1141 / 1143

页数：3

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