HLA SUSCEPTIBILITY GENES IN CELIAC-DISEASE - GENETIC-MAPPING AND ROLE IN PATHOGENESIS

被引：506
作者：
SOLLID, LM
THORSBY, E
机构：
[1] Institute of Transplantation Immunology, University of Oslo, The National Hospital, Oslo
来源：
GASTROENTEROLOGY | 1993年 / 105卷 / 03期
关键词：
D O I：
10.1016/0016-5085(93)90912-V
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The overrepresentation of particular HLA alleles in patients with celiac disease was first noted two decades ago. Several lines of evidence obtained during the last years strongly suggest that a particular HLA-DQ heterodimer, encoded by the DQA1*0501 and DQB1*0201 genes in cis or trans configuration, confers the primary disease susceptibility. This paper reviews the evidence behind this concept and discusses how this particular DQ molecule may be involved in the pathogenesis. © 1993.
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页码：910 / 922
页数：13
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