INHIBITION OF ELECTRICALLY EVOKED CONTRACTIONS OF GUINEA-PIG ILEUM PREPARATIONS MEDIATED BY THE HISTAMINE H3-RECEPTOR

被引：47
作者：
MENKVELD, GJ
TIMMERMAN, H
机构：
[1] Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, 1081 HV Amsterdam
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期
关键词：
(In vitro assay); Electrical field stimulation; Histamine H[!sub]3[!/sub] receptor; Ileum (guinea-pig);
D O I：
10.1016/0014-2999(90)90458-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the contraction responses of isolated guinea-pig ileum preparations under several conditions of electrical field stimulation. Histamine H3-agonists caused a dose-dependent inhibition of both cholinergic and nonadrenergic noncholinergic (NANC) responses (pD2 of histamine, 7.3; Nα-methylhistamine, 8.4; (R)-α-methylhistamine, 8.3); H3-antagonists blocked this inhibition (pA2 of impromidine, 7.2; thioperamide, 8.5). Our results indicate that H3-receptors are present on both cholinergic and NANC nerves in the myenteric plexus and that the preparation can be used as a rapid and simple test system for histamine H3-receptors. © 1990.
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页码：343 / 347
页数：5
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