Pharmacogenetic Testing and Opioids

被引:0
作者
Collins, Tennille [1 ]
Nykamp, Diane [2 ]
机构
[1] Mercer Univ, Coll Pharm, Atlanta, GA USA
[2] Mercer Univ, Coll Pharm, Pharm Practice, Atlanta, GA USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A majority of medications are metabolized by the liver's CYP450 system. Metabolism of specific pain medications differs among individuals due to pharmacogenetic variation. CYP450 genotyping displays the type of metabolizer a patient is, in order to determine drug appropriateness, dosage, and dosing interval. Results of pharmacogenetic tests allow patients to be dosed appropriately and avoid experiencing dose-dependent side effects or lack of drug efficacy. Pharmacists can play a role in providing information to patients on selecting opioids where genetic testing may be useful.
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页码:23 / 26
页数:4
相关论文
共 26 条
  • [1] Allele, GEN HOM REF
  • [2] [Anonymous], ROCH AMPLICHIP CYT P
  • [3] [Anonymous], INF HEALTHC PROF US
  • [4] Development and use of active clinical decision support for preemptive pharmacogenomics
    Bell, Gillian C.
    Crews, Kristine R.
    Wilkinson, Mark R.
    Haidar, Cyrine E.
    Hicks, J. Kevin
    Baker, Donald K.
    Kornegay, Nancy M.
    Yang, Wenjian
    Cross, Shane J.
    Howard, Scott C.
    Freimuth, Robert R.
    Evans, William E.
    Broeckel, Ulrich
    Relling, Mary V.
    Hoffman, James M.
    [J]. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2014, 21 (E1) : E93 - E99
  • [5] Benyamin R, 2008, PAIN PHYSICIAN, V11, pS105
  • [6] Molecular genetics of CYP2D6:: Clinical relevance with focus on psychotropic drugs
    Bertilsson, L
    Dahl, ML
    Dalén, P
    Al-Shurbaji, A
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 53 (02) : 111 - 122
  • [7] Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American college of physicians and the American pain society
    Chou, Roger
    Qaseem, Amir
    Snow, Vincenza
    Casey, Donald
    Cross, J. Thomas, Jr.
    Shekelle, Paul
    Owens, Douglas K.
    [J]. ANNALS OF INTERNAL MEDICINE, 2007, 147 (07) : 478 - 491
  • [8] Cleveland Clinic, MAN AC VS CHRON PAIN
  • [9] Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
    Crews, K. R.
    Gaedigk, A.
    Dunnenberger, H. M.
    Leeder, J. S.
    Klein, T. E.
    Caudle, K. E.
    Haidar, C. E.
    Shen, D. D.
    Callaghan, J. T.
    Sadhasivam, S.
    Prows, C. A.
    Kharasch, E. D.
    Skaar, T. C.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (04) : 376 - 382
  • [10] FDA, TABL PHARM BIOM DRUG