CHANGES OF ANTIOXIDATIVE HOMEOSTASIS IN PATIENTS ON CHRONIC-HEMODIALYSIS

被引：0
作者：
SCHMIDTMANN, S [1 ]
MULLER, M [1 ]
VONBAEHR, R [1 ]
PRECHT, K [1 ]
机构：
[1] HUMBOLDT UNIV,BEREICH MED CHARITE,DEPT MED IMMUNOL,O-1040 BERLIN,GERMANY
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 1991年 / 6卷
关键词：
HEMODIALYSIS; OXIDATIVE METABOLISM; RESPIRATORY BURST; POLYMORPHONUCLEAR LEUKOCYTES; OXIDATIVE DAMAGE; RED BLOOD CELLS; RENAL ANEMIA; HEMOLYSIS;
D O I：
暂无
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
The balance between reactive oxygen species (ROS) generated during metabolism and their scavengers and trappers is changed in patients on chronic haemodialysis. Recently we found an increased superoxide anion-trapping capacity of uraemic serum before haemodialysis which was decreased during the treatment, probably because of loss of antioxidants into the dialysate. In this study the generation of superoxide anions by polymorphonculear leukocytes (PMN) was examined. There was a tendency for decreased ROS generation during transient luekopenia regarding all conditions of PMN incubation and stimulation. The changed antioxidative homeostasis is thought to be one factor of decreased red blood cell (RBC) survival and thereby of renal anaemia in patients on chronic haemodialysis. Our results support this hypothesis, indicating an increased haemolysis ratio of RBC after haemodialysis in a strongly artificial singlet oxygen stress.
引用
收藏
页码：71 / 74
页数：4
相关论文
共 21 条
  • [1] BAUER H, 1983, CONTRIB NEPHROL, V36, P9
  • [2] PATHOGENESIS OF ANEMIA DUE TO RENAL-FAILURE
    BLUMBERG, A
    [J]. NEPHRON, 1989, 51 : 15 - 19
  • [3] ANAPHYLATOXIN FORMATION DURING HEMODIALYSIS - COMPARISON OF NEW AND RE-USED DIALYZERS
    CHENOWETH, DE
    CHEUNG, AK
    WARD, DM
    HENDERSON, LW
    [J]. KIDNEY INTERNATIONAL, 1983, 24 (06) : 770 - 774
  • [4] COHEN MS, 1982, BLOOD, V60, P1283
  • [5] ANEMIA AND CHRONIC RENAL-FAILURE - THE POSSIBLE ROLE OF THE OXIDATIVE STATE OF GLUTATHIONE
    COSTAGLIOLA, C
    ROMANO, L
    SORICE, P
    DIBENEDETTO, A
    [J]. NEPHRON, 1989, 52 (01): : 11 - 14
  • [6] FILLIT H, 1984, NEPHRON, V29, P40
  • [7] JACOBS AA, 1989, NEPHRON, V52, P119
  • [8] HEMATOPORPHYRIN AND HPD - PHOTOPHYSICS, PHOTOCHEMISTRY AND PHOTOTHERAPY
    KESSEL, D
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 39 (06) : 851 - 859
  • [9] SERUM ANTIOXIDANT ACTIVITY IN UREMIC PATIENTS
    KURODA, M
    ASAKA, S
    TOFUKU, Y
    TAKEDA, R
    [J]. NEPHRON, 1985, 41 (03): : 293 - 298
  • [10] LEWIN G, 1988, MED AKT, V14, P130
123