PHOSPHORYLASE - A BIOLOGICAL TRANSDUCER

被引：73
作者：
BROWNER, MF
FLETTERICK, RJ
机构：
[1] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 02期
关键词：
D O I：
10.1016/0968-0004(92)90504-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A transducer is a device that receives energy from one system and transmits it, often in a different form, to another. Glycogen phosphorylase receives information from the cell or organism in the form of metabolic signals. The energy associated with the binding of these ligand signals is integrated and transmitted at an atomic level, allowing precise adjustment of the enzymatic activity. Understanding this elegant allosteric control has required several different approaches, but the structural requirements of allostery are being defined.
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页码：66 / 71
页数：6
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