EFFECT OF CENTRAL CHOLINERGIC STIMULATION ON REGIONAL CEREBRAL BLOOD-FLOW IN ALZHEIMER-DISEASE

被引：124
作者：
GEANEY, DP
SOPER, N
SHEPSTONE, BJ
COWEN, PJ
机构：
[1] JOHN RADCLIFFE HOSP,NUCL MED UNIT,OXFORD OX3 9DU,ENGLAND
[2] UNIV OXFORD,DEPT RADIOL,OXFORD,ENGLAND
[3] LITTLEMORE HOSP,MRC,CLIN PHYSIOL UNIT,OXFORD,ENGLAND
来源：
LANCET | 1990年 / 335卷 / 8704期
关键词：
D O I：
10.1016/0140-6736(90)93028-N
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls. © 1990.
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页码：1484 / 1487
页数：4
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