TRANSDERMAL DRUG TRANSPORT AND METABOLISM .1. COMPARISON OF INVITRO AND INVIVO RESULTS

被引：37

作者：

GUZEK, DB ^{[1
]}

KENNEDY, AH ^{[1
]}

MCNEILL, SC ^{[1
]}

WAKSHULL, E ^{[1
]}

POTTS, RO ^{[1
]}

机构：

[1] PFIZER CENT RES, GROTON, CT 06340 USA

来源：

PHARMACEUTICAL RESEARCH | 1989年 / 6卷 / 01期

关键词：

D O I：

10.1023/A:1015891400924

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：33 / 39

页数：7

共 25 条

[1]

BICKERS DR, 1980, CURRENT CONCEPTS CUT, P95

[2] SKIN STRUCTURE AND METABOLISM - RELEVANCE TO THE DESIGN OF CUTANEOUS THERAPEUTICS [J].

BUCKS, DAW .

PHARMACEUTICAL RESEARCH, 1984, (04) :148-153

[3] GENERAL PHYSICAL MODEL FOR SIMULTANEOUS DIFFUSION AND METABOLISM IN BIOLOGICAL-MEMBRANES - COMPUTATIONAL APPROACH FOR THE STEADY-STATE CASE [J].

FOX, JL ;

YU, CD ;

HIGUCHI, WI ;

HO, NFH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1979, 2 (01) :41-57

[4] PERCUTANEOUS METABOLISM WITH SATURABLE ENZYME-KINETICS [J].

GUY, RH ;

HADGRAFT, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1982, 11 (03) :187-197

[5]

Guy RH, 1985, MODELS DERMATOLOGY, V2, P170

[6]

HADGRAFT J, 1980, INT J PHARM, V4, P229, DOI 10.1016/0378-5173(80)90138-6

[7]

HADGRAFT J, 1985, DESIGN PRODRUGS, P271

[8]

Hoelgaard A., 1986, ADV DRUG DELIVERY SY, P111

[9] A MULTISAMPLE APPARATUS FOR KINETIC EVALUATION OF SKIN PENETRATION INVITRO - THE INFLUENCE OF VIABILITY AND METABOLIC STATUS OF THE SKIN [J].

HOLLAND, JM ;

KAO, JY ;

WHITAKER, MJ .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 72 (02) :272-280

[10]

KAO J, 1987, J PHARMACOL EXP THER, V241, P482

← 1 2 3 →