Platelet derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization

被引：21

作者：

Sadiq, Mohammad Ali ^{[1
]}

Hanout, Mostafa ^{[1
]}

Sarwar, Salman ^{[1
]}

Hassan, Muhammad ^{[1
]}

Do, Diana V. ^{[1
]}

Quan Dong Nguyen ^{[1
]}

Sepah, Yasir Jamal ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Stanley M Truhlsen Eye Inst, Omaha, NE 68198 USA

来源：

SAUDI JOURNAL OF OPHTHALMOLOGY | 2015年 / 29卷 / 04期

关键词：

Platelet derived growth factor; Retinal vascular disease; Age related macular degeneration; Diabetic retinopathy; PDGF;

D O I：

10.1016/j.sjopt.2015.05.005

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy (DR), retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factor (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF plays an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly AMD, has become more exciting due to agents such as PDGF antagonists.

引用

页码：287 / 291

页数：5

共 33 条

[1] Biology of platelet-derived growth factor and its involvement in disease [J].

Alvarez, Ricardo H. ;

Kantarjian, Hagop M. ;

Cortes, Jorge E. .

MAYO CLINIC PROCEEDINGS, 2006, 81 (09) :1241-1257

[2] Role of platelet-derived growth factors in physiology and medicine [J].

Andrae, Johanna ;

Gallini, Radiosa ;

Betsholtz, Christer .

GENES & DEVELOPMENT, 2008, 22 (10) :1276-1312

[3]

[Anonymous], 2013, INTRAVITREOUS ADM CO

[4]

[Anonymous], 2013, MONOTHERAPY

[5] Insight into the physiological functions of PDGF through genetic studies in mice [J].

Betsholtz, C .

CYTOKINE & GROWTH FACTOR REVIEWS, 2004, 15 (04) :215-228

[6] Therapeutic options targeting angiogenesis in nonsmall cell lung cancer [J].

Crino, Lucio ;

Metro, Giulio .

EUROPEAN RESPIRATORY REVIEW, 2014, 23 (131) :79-91

[7]

Demoulin JB, 2012, AM J BLOOD RES, V2, P44

[8]

Dong A, 2013, ANTAGONISM PDGF BB S

[9]

Dugel PU, 2013, ANTI PDGF COMBINATIO

[10]

Dugel PU, 2013, RETINA TODAY

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