EVALUATION OF RAMIPRIL ON BLOOD SUGAR LEVEL AND INTERACTION WITH THE ORAL ANTI-DIABETIC DRUGS IN ALLOXAN-INDUCED DIABETIC RATS

被引：5

作者：

Agrawal, Neeraj K. ^{[1
]}

Gupta, Uma ^{[2
]}

机构：

[1] HIHT Univ, Dept Pharmacol, Dehra Dun, India

[2] Univ Rajasthan, Dept Zool, Jaipur, Rajasthan, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 08期

关键词：

Ramipril; Blood sugar; Alloxaninduced diabetic rats; Oral antidiabetic drugs;

D O I：

10.13040/IJPSR.0975-8232.4(8).2933-38

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The present study investigates the effect of Ramipril on blood sugar level and interaction with the oral anti- diabetic drugs in alloxan induced diabetic rats. Method: Rats were divided into 10 groups (n = 6) where Group I -II were normal and Group III -X were diabetic. Ramipril at the dose of 0.9 mg/kg body weight were administered to the normal and diabetic rats. In diabetic groups, the Ramipril was given concomitantly with the each of three Oral anti- diabetic drugs to find-out the effect on blood sugar level. All drugs administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) was conducted. Results: It was observed that in normal rats the Ramipril slightly reduced the blood sugar level which was insignificant (P>0.05) except at '30' min time point. In contrast in, it exhibited the anti- hyperglycemic activity significantly (P <= 0.01) at all-time points in alloxan induced diabetic rats. Conclusion: The present study has concluded that The Ramipril has significant anti- hyperglycemic activities which accentuate the effect of oral anti- diabetic drugs in alloxan-induced diabetic rats.

引用

页码：2933 / 2938

页数：6

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