A CONVENIENT SYNTHESIS OF A LIPOPEPTIDE CONTAINING A DIACYLGLYCEROL MOIETY - PREPARATION OF A POTENTIAL INHIBITOR OF PROTEIN-KINASE-C

被引：0
作者：
DEBONT, HBA
VANBOOM, JH
LISKAMP, RMJ
机构：
来源：
RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY | 1992年 / 111卷 / 05期
关键词：
DIACYLGLYCEROL PEPTIDE; DIMYRISTOYLGLYCEROL PEPTIDE; SOLID-PHASE SYNTHESIS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of a dimyristoylglycerol peptide is reported. Starting from 1,2-diisopropylidene-sn-glycerol, a 1,2-dimyristoyl-sn-glycerol derivative has been synthesized which has been coupled to an immobilized peptide. After deprotection and cleavage from thc resin, a diacylglycerol-moiety-containing lipopeptide was obtained which can be considered as a potential inhibitor of protein kinase C.
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页码：222 / 226
页数：5
相关论文
共 33 条
[11]   PROTEIN-KINASE-C CONTAINS A PSEUDOSUBSTRATE PROTOTYPE IN ITS REGULATORY DOMAIN [J].
HOUSE, C ;
KEMP, BE .
SCIENCE, 1987, 238 (4834) :1726-1728
[12]   OVERPRODUCTION OF PROTEIN KINASE-C CAUSES DISORDERED GROWTH-CONTROL IN RAT FIBROBLASTS [J].
HOUSEY, GM ;
JOHNSON, MD ;
HSIAO, WLW ;
OBRIAN, CA ;
MURPHY, JP ;
KIRSCHMEIER, P ;
WEINSTEIN, IB .
CELL, 1988, 52 (03) :343-354
[13]   AN X-RAY AND THERMAL EXAMINATION OF THE GLYCERIDES .11. THE 1-2-DIGLYCERIDES, AND FURTHER OBSERVATIONS ON 1-3-DIGLYCERIDES [J].
HOWE, RJ ;
MALKIN, T .
JOURNAL OF THE CHEMICAL SOCIETY, 1951, (OCT) :2663-&
[14]   A SIMPLE REGIOSELECTIVE PARTIAL HYDROLYSIS OF DI-O-ISOPROPYLIDENE MONOSACCHARIDES WITH COPPER(II) ION [J].
IWATA, M ;
OHRUI, H .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1981, 54 (09) :2837-2838
[15]   COMPUTER-ASSISTED MOLECULAR MODELING OF TUMOR PROMOTERS - RATIONALE FOR THE ACTIVITY OF PHORBOL ESTERS, TELEOCIDIN-B, AND APLYSIATOXIN [J].
JEFFREY, AM ;
LISKAMP, RMJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (02) :241-245
[16]  
KISFALUDY L, 1983, SYNTHESIS-STUTTGART, P325
[17]   STRUCTURAL AND FUNCTIONAL ROLES OF GLYCOSYL-PHOSPHATIDYLINOSITOL IN MEMBRANES [J].
LOW, MG ;
SALTIEL, AR .
SCIENCE, 1988, 239 (4837) :268-275
[18]  
MCILHINNEY RAJ, 1990, TRENDS BIOCHEM SCI, V15, P387
[19]  
MORODER L, 1990, SYNTHESIS-STUTTGART, P889
[20]  
NEWKOME GR, 1985, J ORG CHEM, V50, P2004
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