A CONVENIENT SYNTHESIS OF A LIPOPEPTIDE CONTAINING A DIACYLGLYCEROL MOIETY - PREPARATION OF A POTENTIAL INHIBITOR OF PROTEIN-KINASE-C

The synthesis of a dimyristoylglycerol peptide is reported. Starting from 1,2-diisopropylidene-sn-glycerol, a 1,2-dimyristoyl-sn-glycerol derivative has been synthesized which has been coupled to an immobilized peptide. After deprotection and cleavage from thc resin, a diacylglycerol-moiety-containing lipopeptide was obtained which can be considered as a potential inhibitor of protein kinase C.