FACTOR-IX INHIBITORS IN HEMOPHILIA-B PATIENTS - THEIR INCIDENCE AND PROSPECTS FOR DEVELOPMENT WITH HIGH-PURITY FACTOR-IX PRODUCTS

被引：0

作者：

BRIET, E

机构：

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1991年 / 2卷

关键词：

HEMOPHILIA; FACTOR-IX INHIBITORS; IMMUNE TOLERANCE; BREAST FEEDING;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In most respects, haemophilia B with inhibitors against FIX cannot be distinguished from haemophilia A with inhibitors. However, based on a 19 nation survey and on several published reports, inhibitors occur about five-fold less often in haemophilia B than in haemophilia. A. The most interesting question, however, is why most patients do not develop inhibitors. This might be due to materno-foetal transfusions or to the transfer of antigens by breast feeding.

引用

页码：47 / 50

页数：4

共 14 条

[1]

Briet E, 1984, Prog Clin Biol Res, V150, P123

[2] BREAST-FEEDING AND MATERNAL-DONOR RENAL-ALLOGRAFTS - POSSIBLY THE ORIGINAL DONOR-SPECIFIC TRANSFUSION [J].

CAMPBELL, DA ;

LORBER, MI ;

SWEETON, JC ;

TURCOTTE, JG ;

NIEDERHUBER, JE ;

BEER, AE .

TRANSPLANTATION, 1984, 37 (04) :340-344

[3] HEMOPHILIA-B - DATABASE OF POINT MUTATIONS AND SHORT ADDITIONS AND DELETIONS [J].

GIANNELLI, F ;

GREEN, PM ;

HIGH, KA ;

LOZIER, JN ;

LILLICRAP, DP ;

LUDWIG, M ;

OLEK, K ;

REITSMA, PH ;

GOOSSENS, M ;

YOSHIOKA, A ;

SOMMER, S ;

BROWNLEE, GG .

NUCLEIC ACIDS RESEARCH, 1990, 18 (14) :4053-4059

[4]

Gill F M, 1984, Prog Clin Biol Res, V150, P19

[5]

NILSSON IM, 1990, PROG CLIN BIOL RES, V324, P69

[6] INDUCTION OF SPLIT TOLERANCE AND CLINICAL CURE IN HIGH-RESPONDING HEMOPHILIACS WITH FACTOR-IX ANTIBODIES [J].

NILSSON, IM ;

BERNTORP, E ;

ZETTERVALL, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) :9169-9173

[7] HUMAN RECOMBINANT DNA-DERIVED ANTIHEMOPHILIC-FACTOR (FACTOR-VIII) IN THE TREATMENT OF HEMOPHILIA-A [J].

SCHWARTZ, RS ;

ABILDGAARD, CF ;

ALEDORT, LM ;

ARKIN, S ;

BLOOM, AL ;

BRACKMANN, HH ;

BRETTLER, DB ;

FUKUI, H ;

HILGARTNER, MW ;

INWOOD, MJ ;

KASPER, CK ;

KERNOFF, PBA ;

LEVINE, PH ;

LUSHER, JM ;

MANNUCCI, PM ;

SCHARRER, I ;

MACKENZIE, MA ;

PANCHAM, N ;

KUO, HS ;

ALLRED, RU .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (26) :1800-1805

[8] INCIDENCE OF INHIBITORS IN PATIENTS WITH SEVERE AND MODERATE HEMOPHILIA-A TREATED WITH FACTOR-VIII CONCENTRATES [J].

SCHWARZINGER, I ;

PABINGER, I ;

KORNINGER, C ;

HASCHKE, F ;

KUNDI, M ;

NIESSNER, H ;

LECHNER, K .

AMERICAN JOURNAL OF HEMATOLOGY, 1987, 24 (03) :241-245

[9]

Shapiro S S, 1984, Prog Clin Biol Res, V150, P45

[10]

SHAPIRO S S, 1975, Seminars in Thrombosis and Hemostasis, V1, P336

← 1 2 →