DETERMINATION OF BENZYDAMINE AND ITS N-OXIDE IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：25
作者：
BALDOCK, GA
BRODIE, RR
CHASSEAUD, LF
TAYLOR, T
机构：
[1] Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, Cambridgeshire
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 01期
关键词：
D O I：
10.1016/S0378-4347(00)83812-8
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine in plasma was 0.5 ng/ml and that in urine 1 ng/ml; the limit of reliable determination of benzydamine N-oxide in urine was 50 ng/ml. The method has been successfully applied to the analysis of these compounds in biological fluids after administration of intravenous and oral doses of benzydamine to human volunteers. © 1990.
引用
收藏
页码：113 / 123
页数：11
相关论文
共 8 条
  • [1] ANDERSSON K, 1974, ARZNEIMITTELFORSCH, V24, P1686
  • [2] BENSON HAE, 1987, J CHROMATOGR, V394, P395
  • [3] HPLC DETERMINATION OF BENZYDAMINE AND ITS METABOLITE N-OXIDE IN PLASMA FOLLOWING ORAL-ADMINISTRATION OR TOPICAL APPLICATION IN MAN, USING FLUOROMETRIC DETECTION
    CATANESE, B
    LAGANA, A
    MARINO, A
    PICOLLO, R
    ROTATORI, M
    [J]. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1986, 18 (04): : 385 - 403
  • [4] CHASSEAUD LF, 1985, INT J TISSUE REACT, V7, P195
  • [5] KOPPEL C, 1985, ARZNEIMITTEL-FORSCH, V35-1, P634
  • [6] MAAMER M, 1987, International Journal of Tissue Reactions, V9, P135
  • [7] MAHON WA, 1985, INT J TISSUE REACT, V7, P229
  • [8] SCHOENWALD RD, 1987, INT J TISSUE REACT, V9, P93
1