Overview of antiarrhythmic drug therapy for supraventricular tachycardia in children

被引:11
作者
Escudero, Carolina [1 ]
Carr, Roxane [1 ]
Sanatani, Shubhayan [1 ]
机构
[1] British Columbia Childrens Hosp, 4480 Oak St, Vancouver, BC V6H 3V4, Canada
关键词
Supraventricular tachycardia; Pediatric; Antiarrhythmic; Pharmacology; Classification;
D O I
10.1016/j.ppedcard.2012.11.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Antiarrhythmic drug therapy remains the mainstay of therapy for pediatric supraventricular tachycardia (SVT). In order to appropriately treat pediatric arrhythmias pharmacologically, an understanding of the mechanisms of action, efficacy, adverse effects, and interactions for the different antiarrhythmics is required. This article provides an overview of the pharmacologic treatment options for children with SVT. We review the classification systems, mechanisms of action, pharmacokinetics, and pharmacodynamics of the available antiarrhythmics used in pediatric SVT. We also outline the side effects, drug interactions, and evidence available for the efficacy of these different medications in the pediatric age group. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:55 / 63
页数:9
相关论文
共 107 条
[31]   SUPRAVENTRICULAR TACHYCARDIA IN CHILDREN - CLINICAL-FEATURES, RESPONSE TO TREATMENT, AND LONG-TERM FOLLOW-UP IN 217 PATIENTS [J].
GARSON, A ;
GILLETTE, PC ;
MCNAMARA, DG .
JOURNAL OF PEDIATRICS, 1981, 98 (06) :875-882
[32]   USEFULNESS OF INTRAVENOUS PROPAFENONE FOR CONTROL OF POSTOPERATIVE JUNCTIONAL ECTOPIC TACHYCARDIA [J].
GARSON, A ;
MOAK, JP ;
SMITH, RT ;
NORTON, JB .
AMERICAN JOURNAL OF CARDIOLOGY, 1987, 59 (15) :1422-1424
[33]   AMIODARONE TREATMENT OF CRITICAL ARRHYTHMIAS IN CHILDREN AND YOUNG-ADULTS [J].
GARSON, A ;
GILLETTE, PC ;
MCVEY, P ;
HESSLEIN, PS ;
PORTER, CBJ ;
ANGELL, LK ;
KALDIS, LC ;
HITTNER, HM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1984, 4 (04) :749-755
[34]  
Gbadebo TG, 2000, CARD ELECTROPHYSIOL, V4, P312
[35]   Electrophysiological effects of ibutilide in patients with accessory pathways [J].
Glatter, KA ;
Dorostkar, PC ;
Yang, YF ;
Lee, RJ ;
Van Hare, GF ;
Keung, E ;
Modin, G ;
Scheinman, MM .
CIRCULATION, 2001, 104 (16) :1933-1939
[36]  
Gow RM, 1996, CAN J CARDIOL, V12, P1157
[38]   TREATMENT OF PAROXYSMAL SUPRA-VENTRICULAR TACHYCARDIA IN INFANCY WITH DIGITALIS, ADENOSINE-5'-TRIPHOSPHATE, AND VERAPAMIL - A COMPARATIVE-STUDY [J].
GRECO, R ;
MUSTO, B ;
ARIENZO, V ;
ALBORINO, A ;
GAROFALO, S ;
MARSICO, F .
CIRCULATION, 1982, 66 (03) :504-508
[39]   Characteristics, management, and midterm outcome in infants with atrioventricular nodal reentry tachycardia [J].
Gross, GJ ;
Epstein, MR ;
Walsh, EP ;
Saul, JP .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (08) :956-960
[40]   The safety and efficacy of ibutilide in children and in patients with congenital heart disease [J].
Hoyer, Andrew W. ;
Balaji, Seshadri .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2007, 30 (08) :1003-1008