Creutzfeldt-Jakob disease and the eye

被引：1
作者：
Head, Mark W. [1 ]
Ironside, James W. [1 ]
机构：
[1] Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Div Pathol,Natl Creutzfeldt Jakob Dis Surveillan, Edinburgh EH4 2XU, Midlothian, Scotland
来源：
EXPERT REVIEW OF OPHTHALMOLOGY | 2008年 / 3卷 / 04期
关键词：
corneal transplantation; decontamination; iatrogenic CJD; infectivity; optic nerve; prion protein; retina; sporadic CJD; variant CJD;
D O I：
10.1586/17469899.3.4.481
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Creutzfeldt-Jakob disease (CJD) belongs to the group of human prion diseases - rare neurodegenerative disorders that are caused by transmissible agents known as prions. In CJD, the levels of prion infectivity are highest in the brain, and there is evidence from experimental models that similar levels of infectivity are likely to be present in the retina and optic nerve. CJD has been transmitted by corneal transplantation and there have been increasing concerns that transmission by ophthalmic surgery (particularly retinal surgery) is a possibility. This article outlines the current information on ocular tissue involvement in CJD, discusses concerns regarding the risk of potential transmission and addresses current issues for risk management in ophthalmic surgery.
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页码：481 / 490
页数：10
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