STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYL-SUBSTITUTED ISOXAZOLIDINO[4,3-C]-CHROMAN-4-ONES AND ISOXAZOLIDINO[4,3-C]-QUINOLIN-4-ONES VIA INTRAMOLECULAR NITRONE CYCLOADDITION

被引：0
作者：
ARNONE, A
BRUCHE, L
GARANTI, L
ZECCHI, G
机构：
[1] POLITECN MILAN,DIPARTIMENTO CHIM,I-20131 MILAN,ITALY
[2] CNR,CTR STUDIO SOSTANZE ORGAN NAT,I-20131 MILAN,ITALY
[3] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY
来源：
JOURNAL OF CHEMICAL RESEARCH-S | 1995年 / 07期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A three-step synthesis of trifluoromethyl-substituted isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones is described, where the key feature is an intramolecular 1,3-dipolar cycloaddition of C-aryl-N-benzylnitrones bearing a trifluoromethyl-substituted alkene function.
引用
收藏
页码：282 / 283
页数：2
相关论文
共 50 条
[1]   Enantioselective intramolecular nitrone cycloaddition route to 3-(trifluoromethyl)-isoxazolidino[4,3-c]-chroman-4-ones and -quinolin-4-ones [J].
Arnone, A ;
Broggini, G ;
Bruche, L ;
Molteni, G ;
Zecchi, G .
JOURNAL OF CHEMICAL RESEARCH-S, 1998, (04) :188-189
[2]   SYNTHESIS AND BINDING-STUDIES OF 1-ARYLPYRAZOLO[4,5-C]QUINOLIN-4-ONES AND 2-ARYLPYRAZOLO[4,3-C]QUINOLIN-4-ONES .1. [J].
CECCHI, L ;
MELANI, F ;
PALAZZINO, G ;
FILACCHIONI, G ;
MARTINI, C ;
PENNACCHI, E ;
LUCACCHINI, A .
FARMACO-EDIZIONE SCIENTIFICA, 1985, 40 (07) :509-516
[3]   Synthesis of pyrazolo[4,3-c]quinolin-4-ones and indolo[3,2-c]quinolin-6-ones by the photocyclization of N-aryl-o-chloroheteroarenecarboxamides [J].
Lu, Shenci ;
Zhang, Wei ;
Pan, Jinhui ;
Zhang, Jie .
SYNTHESIS-STUTTGART, 2008, (10) :1517-1522
[4]   Synthetic approaches for the construction of 2,5-disubstituted pyrazolo[4,3-c]quinolin-3-ones and pyrazolo[4,3-c]cinnolin-3-ones [J].
Beshore, Douglas C. ;
Johnson, Adam W. ;
Pitts, Daniel R. ;
DiPardo, Robert M. ;
Cofre, Victoria ;
Kuduk, Scott D. .
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
[5]   Synthesis of New Substituted Chromen[4,3-c]pyrazol-4-ones and Their Antioxidant Activities [J].
Al-Ayed, Abdullah Sulaiman .
MOLECULES, 2011, 16 (12) :10292-10302
[6]   Preparation of 2,4,5-trisubstituted pyrazolo[4,3-c]quinolin-3-ones [J].
Beshore, Douglas C. ;
DiPardo, Robert M. ;
Kuduk, Scott D. .
TETRAHEDRON LETTERS, 2010, 51 (06) :970-973
[7]   SYNTHESIS OF QUINO(4,3-C)QUINOLINE DERIVATIVESAND POLYCARBOCYCLIC QUINO(4,3-C)QUINOLINES [J].
KOBAYASH.T ;
KIKUMOTO, R .
TETRAHEDRON, 1965, 21 (08) :1903-&
[8]   Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction approach [J].
Palka, Barbara ;
Di Capua, Angela ;
Anzini, Maurizio ;
Vilkauskaite, Gyte ;
Sackus, Algirdas ;
Holzer, Wolfgang .
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 10 :1759-1764
[9]   Synthesis of the new pyrazolo[4,3-c]pyrrolizine skeleton via intramolecular nitrilimine cycloaddition [J].
Molteni, G .
HETEROCYCLES, 2004, 63 (06) :1423-1428
[10]   Synthesis and antiviral activities of new pyrazolo[4,3-c]quinolin-3-ones and their ribonucleoside derivatives [J].
de Oliveira, MRP ;
Alves, TR ;
Pinto, AC ;
Pereira, HD ;
Leao-Ferreira, LR ;
Moussatché, N ;
Frugulhetti, ICDP ;
Ferreira, VF ;
de Souza, MCBV .
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (05) :735-748
12345