A FLEXIBLE APPROACH TO SYNTHETIC LIPID AMMONIUM-SALTS FOR POLYNUCLEOTIDE TRANSFECTION

被引：32

作者：

BENNETT, MJ

MALONE, RW

NANTZ, MH

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

[2] UNIV CALIF DAVIS,DEPT MED PATHOL,DAVIS,CA 95616

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 13期

关键词：

D O I：

10.1016/0040-4039(95)00276-I

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel 2,3-acyloxy-1-propylammonium salts is described. The route incorporates the use of glycidol and N-methyl-2-aminoethanol to prepare cationic lipids with control of absolute stereochemistry and regioselective introduction of fatty acid side chains.

引用

页码：2207 / 2210

页数：4

共 26 条

[1] CORRELATION BETWEEN PHYSICOCHEMICAL CHARACTERISTICS OF SYNTHETIC CATIONIC AMPHIPHILES AND THEIR DNA TRANSFECTION ABILITY [J].