ARTIFICIAL ALLOSTERIC RECEPTORS FOR NUCLEOTIDE BASES AND ALKALI-METAL CATIONS

被引：56

作者：

INOUYE, M

KONISHI, T

ISAGAWA, K

机构：

[1] Department of Applied Materials Science, University of Osaka Prefecture, Sakai

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 18期

关键词：

D O I：

10.1021/ja00071a021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New allosteric thymine receptors, 2,6-diamidopyridine derivatives tethered to an anthracene ring by a polyoxyethylene chain, were synthesized. In these receptors, binding of 1-butylthymine was enhanced by a factor of 4-6 by recognition of sodium cations, and the changes in the electron density of the anthracene ring were found to have influence on the allosterism by through-space interaction. The anthracene-linked diamidopyridines represent a rationally designed new class of artificial allosteric receptors.

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页码：8091 / 8095

页数：5

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