HUMAN AUTOANTIBODIES AGAINST THE 70-KD POLYPEPTIDE OF U1 SMALL NUCLEAR RNP ARE ASSOCIATED WITH HLA-DR4 AMONG CONNECTIVE-TISSUE DISEASE PATIENTS

被引：79
作者：
HOFFMANN, RW
RETTENMAIER, LJ
TAKEDA, Y
HEWETT, JE
PETTERSSON, I
NYMAN, U
LUGER, AM
SHARP, GC
机构：
[1] UNIV MISSOURI, DEPT MED, DIV IMMUNOL & RHEUMATOL, COLUMBIA, MO 65201 USA
[2] UNIV MISSOURI, DEPT PATHOL, COLUMBIA, MO 65201 USA
[3] KAROLINSKA INST, DEPT MED CELL GENET, S-10401 STOCKHOLM 60, SWEDEN
[4] UNIV MISSOURI, DEPT STAT & BIOSTAT, CORE GRP, COLUMBIA, MO 65201 USA
来源：
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 05期
关键词：
D O I：
10.1002/art.1780330509
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Serum samples from patients with connective tissue disease (CTD) were characterize using a recently developed enzyme‐linked immunosorbent assay for reactivity with individual specific polypeptides of U1 small nuclear ribonucleoproteins, including the U1‐70‐kd protein. The distribution of HLA antigens was compared in CTD patients with and in those without anti‐U1‐70‐kd autoantibodies and in normal controls. The frequencies of HLA‐DR4 and HLA‐DRw53 were increased among the anti‐U1‐70‐kd autoantibody positive CTD group compared with the frequencies in anti‐U1‐70‐kd autoantibody negative systemic lupus erythematosus patients and compared with normal controls. We conclude that the presence of autoantibodies reactive with the anti‐U1‐70‐kd protein antigen is associated with HLA‐DR4 and HLA‐DRw53. Copyright © 1990 American College of Rheumatology
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页码：666 / 673
页数：8
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