PYOCYANIN FROM PSEUDOMONAS-AERUGINOSA INHIBITS PROSTACYCLIN RELEASE FROM ENDOTHELIAL-CELLS

被引：23
作者：
KAMATH, JM
BRITIGAN, BE
COX, CD
SHASBY, DM
机构：
[1] UNIV IOWA,COLL MED,DEPT MED,IOWA CITY,IA 52242
[2] VET ADM MED CTR,IOWA CITY,IA 52242
来源：
INFECTION AND IMMUNITY | 1995年 / 63卷 / 12期
关键词：
D O I：
10.1128/IAI.63.12.4921-4923.1995
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might alter vascular homeostasis in the absence of cytolysis.
引用
收藏
页码：4921 / 4923
页数：3
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