IN-VITRO ANTIMALARIAL ACTIVITY OF QUASSINOIDS FROM EURYCOMA-LONGIFOLIA AGAINST MALAYSIAN CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM ISOLATES

被引：70

作者：

ANG, HH ^{[1
]}

CHAN, KL ^{[1
]}

MAK, JW ^{[1
]}

机构：

[1] INST MED RES,DIV FILARIA & MALARIA,KUALA LUMPUR 50588,MALAYSIA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 02期

关键词：

D O I：

10.1055/s-2006-958042

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta,18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 mu M, 0.389-3.498 mu M, and 0.504-2.343 mu M, respectively, compared with 0.323-0.774 mu M for chloroquine.

引用

页码：177 / 178

页数：2

共 10 条

[1]

ANG HH, 1990, 26TH ANN SCI SEM MAL, pP8

[2] 13-BETA,18-DIHYDROEURYCOMANOL, A QUASSINOID FROM EURYCOMA-LONGIFOLIA [J].

CHAN, KL ;

LEE, SP ;

SAM, TW ;

TAN, SC ;

NOGUCHI, H ;

SANKAWA, U .

PHYTOCHEMISTRY, 1991, 30 (09) :3138-3141

[3] A QUASSINOID GLYCOSIDE FROM THE ROOTS OF EURYCOMA-LONGIFOLIA [J].

CHAN, KL ;

LEE, SP ;

SAM, TW ;

HAN, BH .

PHYTOCHEMISTRY, 1989, 28 (10) :2857-2859

[4]

CHAN KL, 1986, PLANTA MED, V52, P105

[5]

Gimlette JD, 1977, DICT MALAYAN MED, P183

[6]

Perry LM, 1980, MED PLANTS E SE ASIA, P389

[7] VARIABILITY IN DRUG SUSCEPTIBILITY AMONGST CLONES AND ISOLATES OF PLASMODIUM-FALCIPARUM [J].

THAITHONG, S ;

BEALE, GH ;

CHUTMONGKONKUL, M .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1988, 82 (01) :33-36

[8]

TRAGER W, 1976, SCIENCE, V193, P673, DOI 10.1126/science.781840

[9]

TRAGER W, 1977, B WORLD HEALTH ORGAN, V5, P363

[10]

1982, WHO821 MAL ACT PROGR, P1

← 1 →