MICROSATELLITE POLYMORPHISMS AT THE GLUCOKINASE LOCUS - A POPULATION ASSOCIATION STUDY IN CAUCASIAN TYPE-2 DIABETIC SUBJECTS

被引：6

作者：

HATTERSLEY, AT

SAKER, PJ

COOK, JTE

STRATTON, IM

PATEL, P

PERMUTT, MA

TURNER, RC

WAINSCOAT, JS

机构：

[1] Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford

[2] Department of Haematology, John Radcliffe Hospital, Oxford

[3] Division of Metabolism, Washington University School of Medicine, St Louis

来源：

DIABETIC MEDICINE | 1993年 / 10卷 / 08期

关键词：

GLUCOKINASE; TYPE-2; DIABETES; CAUCASIAN; LINKAGE DISEQUILIBRIUM; POPULATION ASSOCIATION;

D O I：

10.1111/j.1464-5491.1993.tb00150.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucokinase has a central role in glucose metabolism in pancreatic beta cells and hepatocytes and is an important candidate gene for Type 2 diabetes. Mutations of the glucokinase gene have been reported in Caucasian pedigrees with maturity-onset diabetes of the young and late-onset Type 2 diabetes. In population studies of American Blacks and Mauritian Creoles an association between alleles of a glucokinase polymorphism and Type 2 diabetes has been described. Two microsatellite polymorphisms (GCK 1 and GCK 2) flanking the glucokinase gene were investigated in Caucasian subjects. There was no significant linkage disequilibrium between the alleles of the two polymorphisms. The overall allelic frequencies for GCK 1 and the combined haplotypes did not significantly differ between 95 Type 2 diabetic and 76 normoglycaemic subjects. In an expanded cohort of 151 diabetic subjects the allelic frequencies at GCK 2 were also similar to controls. These results suggest that a single mutation of the glucokinase gene is not a common cause of Type 2 diabetes in English Caucasians.

引用

页码：694 / 698

页数：5

共 23 条

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