SUBSTITUTED PENTAPEPTIDES AND HEXAPEPTIDES AS POTENT INHIBITORS OF HERPES-SIMPLEX VIRUS TYPE-2 RIBONUCLEOTIDE REDUCTASE

被引：14

作者：

CHANG, LL ^{[1
]}

HANNAH, J ^{[1
]}

ASHTON, WT ^{[1
]}

RASMUSSON, GH ^{[1
]}

IKELER, TJ ^{[1
]}

PATEL, GF ^{[1
]}

GARSKY, V ^{[1
]}

UNCAPHER, C ^{[1
]}

YAMANAKA, G ^{[1
]}

MCCLEMENTS, WL ^{[1
]}

TOLMAN, RL ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD, W POINT, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80215-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modifications of the Tyr, Asn, and Leu residues of YVVNDL, a peptide which is equipotent to YAGAVVNDL in the inhibition of herpes simplex virus type 2 ribonucleotide reductase (HSV-2 RR), have produced peptides which are as much as 90- to 120-times as potent as YAGAVVNDL in vitro against HSV-2 RR. The chemistry and the structure activity relationships of these inhibitors are described.

引用

页码：1207 / 1212

页数：6

共 28 条

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[Anonymous], 1984, PRACTICE PEPTIDE SYN

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