CORRELATION OF LIPOPHILICITY TO BIODISTRIBUTION OF TC-99M-LABELED AMINOTHIOLS

被引：8
|
作者：
PAPADOPOULOS, M [1 ]
CHIOTELLIS, E [1 ]
VARVARIGOU, A [1 ]
MASTROSTAMATIS, S [1 ]
COTSYFAKIS, C [1 ]
VAVOURAKI, H [1 ]
STATHAKI, S [1 ]
机构：
[1] NCSR DEMOKRITOS,INST RADIOISOTOPES & RADIODIAGNOST,RADIOPHARMACEUT LAB,GR-15310 ATHENS,GREECE
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 01期
关键词：
D O I：
10.1016/0969-8051(93)90142-H
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A series of Tc-99m-DADT complexes substituted with heterocyclic amines were synthesized and tested for their ability to cross the BBB. Each Tc-99m-DADT complex analysed by HPLC was found to consist of two epimers. The more lipophilic epimers were biodistributed in mice. The data demonstrated a significant brain uptake (3-12% dose/g whole brain) and a high lung accumulation (11-85% dose/g) at 2 min p.i. Between the partition coefficients of the technetium complexes, a linear correlation for lung accumulation was observed, while a parabolic curve for brain uptake was found.
引用
收藏
页码：101 / 104
页数：4
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