C-GLYCOSIDES .9. STEREOSPECIFIC SYNTHESIS OF C-GLYCOSIDIC SPIROKETAL OF THE PAPULACANDINS

被引：43

作者：

CZERNECKI, S

PERLAT, MC

机构：

[1] Laboratoire de Chimie des Glucides, Université Pierre et Marie Curie, 75005 Paris, T 74, E6, 4, place Jussieu

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 22期

关键词：

D O I：

10.1021/jo00022a014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of ortho-lithiated triphenylmethyl benzyl ether with perbenzylated D-gluconolactone 1 followed by cyclization by BF3.Et2O provides a new stereospecific synthesis of C-glycosidic spiroketals. The structure of the peracetylated derivative was determined by X-ray diffraction. This methodology is applied to the synthesis of the spiroketal unit of papulacandins.

引用

页码：6289 / 6292

页数：4

共 20 条

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