EFFECT OF CAPTOPRIL ON ISOPROTERENOL-INDUCED MYOCARDIAL ORNITHINE DECARBOXYLASE ACTIVITY

被引：7

作者：

SHIMIZU, M

IRIMAJIRI, O

NAKANO, T

MIZOKAMI, T

OGAWA, K

SANJO, J

YAMADA, H

SASAKI, H

ISOGAI, Y

机构：

[1] Third Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1991年 / 23卷 / 06期

关键词：

RAT; ORNITHINE DECARBOXYLASE; ISOPROTERENOL; CAPTOPRIL; RENIN ANGIOTENSIN SYSTEM; CARDIAC HYPERTROPHY;

D O I：

10.1016/0022-2828(91)90976-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation. Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in biosynthesis of polyamines. In this study, we evaluated the pathophysiological role of the renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial ODC activity as an indicator of cadiac hypertrophy. Isoproterenol caused an eight-fold increase of myocardial ODC activity in normotensive Wistar rats within 4 h after injection. Captopril suppressed the induction of ODC by isoproterenol to two-thirds of the control level. These results indicate that the renin-angiotensin system may participate in the induction of myocardial hypertrophy by isoproterenol. © 1991.

引用

页码：665 / 670

页数：6

共 34 条

[1]

ANTONACCIO MJ, 1981, HYPERTENSION, V3, P54

[2] ROLE OF POLYAMINES IN ISOPROTERENOL-INDUCED CARDIAC-HYPERTROPHY - EFFECTS OF ALPHA-DIFLUOROMETHYLORNITHINE, AN IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE [J].