ANTIBODIES RAISED AGAINST DIFFERENT PORTIONS OF A4 PROTEIN IDENTIFY A SUBSET OF PLAQUES IN DOWNS-SYNDROME

被引：50

作者：

SPARGO, E ^{[1
]}

LUTHERT, PJ ^{[1
]}

ANDERTON, BH ^{[1
]}

BRUCE, M ^{[1
]}

SMITH, D ^{[1
]}

LANTOS, PL ^{[1
]}

机构：

[1] INST PSYCHIAT,DEPT NEUROSCI,LONDON SE5 8AF,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

A4; protein; Alzheimer's disease; Dentate gyrus; Down's syndrome; Immunohistochemistry; Pathogenesis; Senile plaque;

D O I：

10.1016/0304-3940(90)90480-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antisera were raised to peptides corresponding to residues 1-10 and 12-28 of the published sequence of A4 protein, a 42 43 amino acid long peptide isolated from the brains of patients with Down's syndrome and Alzheimer's disease. Immunohistochemical studies performed on sections of temporal lobe from 12 cases of Down's syndrome showed that the number of senile plaques in the molecular layer of the dentate gyrus which were identified by antibody to A4(1-10) was only 23% (range 11-53%) of that recognised by antibody to A4(12-28). This observation has important consequences for both the diagnosis and the pathogenesis of Down's syndrome and Alzheimer's disease. © 1990.

引用

页码：345 / 350

页数：6

共 19 条

[1] MONOCLONAL-ANTIBODIES RAISED AGAINST A SUBSEQUENCE OF SENILE PLAQUE CORE PROTEIN REACT WITH PLAQUE CORES, PLAQUE PERIPHERY AND CEREBROVASCULAR AMYLOID IN ALZHEIMERS-DISEASE [J].