GLYCOGEN-SYNTHASE KINASE 3-BETA IS IDENTICAL TO TAU-PROTEIN KINASE-I GENERATING SEVERAL EPITOPES OF PAIRED HELICAL FILAMENTS

被引：361

作者：

ISHIGURO, K

SHIRATSUCHI, A

SATO, S

OMORI, A

ARIOKA, M

KOBAYASHI, S

UCHIDA, T

IMAHORI, K

机构：

[1] NIHON UNIV,COLL PHARM,FUNABASHI,CHIBA 274,JAPAN

[2] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

FEBS LETTERS | 1993年 / 325卷 / 03期

关键词：

TAU PROTEIN; PROTEIN KINASE; PHOSPHORYLATION; PAIRED HELICAL FILAMENT; ALZHEIMERS DISEASE; GLYCOGEN SYNTHASE KINASE 3-BETA;

D O I：

10.1016/0014-5793(93)81066-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3beta (GSK3beta). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3beta.

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页码：167 / 172

页数：6

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