Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies

被引：6
|
作者：
Nilamgiri, Goswami [1 ]
Garima, Joshi [1 ]
Krutika, Sawant [1 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, TIFAC Ctr Relevance & Excellence, Vadodara, Gujarat, India
来源：
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2012年 / 4卷 / 05期
关键词：
Valacyclovir hydrochloride; microspheres;
D O I：
10.4103/0975-7406.94118
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Floating microspheres are multiple unit Gastroretentive drug delivery systems. Valacyclovir hydrochloride (VCH) is L-valyl ester prodrug of acyclovir. VCH degrades in intestinal fluid. The objective was to develop floating microspheres of VCH to localise the drug at upper part of GIT, for improved absorption. Floating microspheres were prepared by W/O emulsification solvent evaporation method using Ethylcellulose (EC) as polymer. Particle size and % EE were 550.021 +/- 0.241 mm, 79.88 +/- 2.236% respectively. in vitro and in vivo floatability studies confirmed floating behaviour of microspheres. VCH loaded floating microspheres can be a suitable alternative to the conventional formulation, by localizing the drug at upper GIT.
引用
收藏
页码：S8 / S9
页数：2
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