Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies

被引：6
|
作者：
Nilamgiri, Goswami [1 ]
Garima, Joshi [1 ]
Krutika, Sawant [1 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, TIFAC Ctr Relevance & Excellence, Vadodara, Gujarat, India
来源：
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2012年 / 4卷 / 05期
关键词：
Valacyclovir hydrochloride; microspheres;
D O I：
10.4103/0975-7406.94118
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Floating microspheres are multiple unit Gastroretentive drug delivery systems. Valacyclovir hydrochloride (VCH) is L-valyl ester prodrug of acyclovir. VCH degrades in intestinal fluid. The objective was to develop floating microspheres of VCH to localise the drug at upper part of GIT, for improved absorption. Floating microspheres were prepared by W/O emulsification solvent evaporation method using Ethylcellulose (EC) as polymer. Particle size and % EE were 550.021 +/- 0.241 mm, 79.88 +/- 2.236% respectively. in vitro and in vivo floatability studies confirmed floating behaviour of microspheres. VCH loaded floating microspheres can be a suitable alternative to the conventional formulation, by localizing the drug at upper GIT.
引用
收藏
页码：S8 / S9
页数：2
相关论文
共 50 条
  • [1] Floating Microspheres of Lafutidine: Formulation, Optimization, Characterization, in-vitro and in-vivo Floatability Studies Using Eudragit Grades
    Kumar, Sunil
    Tiwari, Abhishek
    Goyal, Naveen
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2022, 56 (03) : 681 - 688
  • [2] DEVELOPMENT AND IN VITRO CHARACTERIZATION OF FLOATING MICROSPHERES BEARING TRAMADOL HCl
    Chaurasia, Deepti
    Kaushik, Kovidendra
    Bhardwaj, Peeyush
    Chaurasia, Himanshu
    Jain, Sanjay K.
    Shobhna, Singh
    ACTA POLONIAE PHARMACEUTICA, 2011, 68 (05): : 795 - 801
  • [3] Gastroretentive Floating Microspheres of Carvedilol: Preparation, In Vitro and In Vivo Characterization
    Zhang, Wen-Qi
    Chen, Li-Bo
    An, Zhe
    Liu, Guo-Hui
    Zhang, Liang
    Wang, Yue-Hui
    Shao, Yan-Kun
    Liu, Ying-Ying
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2016, 6 (01) : 74 - 78
  • [4] Formulation and in vivo evaluation of Floating Microspheres of Misoprostal
    Vanitha, Kondi
    Varma, Mohan
    Alluri, Ramesh
    FASEB JOURNAL, 2012, 26
  • [5] Inhalable liposomal dry powder of gemcitabine-HCl: Formulation, in vitro characterization and in vivo studies
    Gandhi, Manit
    Pandya, Tosha
    Gandhi, Ravi
    Patel, Sagar
    Mashru, Rajashree
    Misra, Ambikanandan
    Tandel, Hemal
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 496 (02) : 886 - 895
  • [6] Bioavailability enhancement of baclofen by gastroretentive floating formulation: statistical optimization, in vitro and in vivo pharmacokinetic studies
    Thakar, Krishna
    Joshi, Garima
    Sawant, Krutika K.
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2013, 39 (06) : 880 - 888
  • [7] Floating drug delivery system of itraconazole: Formulation, in vitro and in vivo studies
    Gokbulut, Eda
    Vural, Imran
    Asikoglu, Makbule
    Ozdemir, Nurten
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 49 : 491 - 501
  • [8] Formulation, characterization and in vitro evaluation of floating microspheres of famotidine as a gastro retentive dosage form
    Jain, Abhishek Kumar
    Jain, C. P.
    Tanwar, Y. S.
    Naruka, P. S.
    ASIAN JOURNAL OF PHARMACEUTICS, 2009, 3 (03) : 222 - 226
  • [9] Formulation, Optimization, in vitro and in-vivo evaluation of levofloxacin hemihydrate Floating Tablets
    Arshad, Muhammad Sohail
    Kiran, Munazza
    Mudassir, Jahanzeb
    Farhan, Muhammad
    Hussain, Amjad
    Abbas, Nasir
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 58
  • [10] The Oral Administration of Lidocaine HCl Biodegradable Microspheres: Formulation and Optimization
    ALQuadeib, Bushra T.
    Eltahir, Eram K. D.
    Alagili, Modhi F.
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 857 - 869
12345