THIO AND NITROGEN ANALOGS OF ACRONYCINE

被引：1

作者：

GEEWANANDA, YA ^{[1
]}

GUNAWARDANA, P ^{[1
]}

CORDELL, GA ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1995年 / 18卷 / 03期

关键词：

ACRONYCINE; THIO ANALOGS; NITROGEN ANALOGS; CONFIGURATION ASSIGNMENTS;

D O I：

10.1007/BF02979195

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thio, thio acetyl, oxime, and several hydrazone and azine derivatives of the antitumor alkaloid acronycine (1) were prepared. NMR spectroscopy was used to study the configurations around the C=N double bond in these acronycine derivatives. In the hydrazones and azines of acronycine the N-N bond assumes a syn configuration to the G-OCH, group, while the N-O bond in the oxime and the N-N bond in noracronycine hydrazone and azines assumes an anti configuration.

引用

页码：195 / 202

页数：8

共 15 条

[1] BOURNE DWA, 1979, J PHARM SCI, V66, P628
[2] Cordell G. A, 1985, ALKALOIDS NY, V25, P1
[3] DIBELLA EP, 1974, Patent No. 3843678
[4] FORMATION OF A THIO ANALOG OF NORACRONINE
DIMMOCK, JR
REPTA, AJ
KAMINSKI, JJ
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (01) : 36 - 39
[5] CHEMISTRY OF ACRONYCINE .2. DIMERIZATION OF NORACRONYCINE
FUNAYAMA, S
CORDELL, GA
WAGNER, H
LOTTER, HL
[J]. JOURNAL OF NATURAL PRODUCTS, 1984, 47 (01): : 143 - 154
[6] Gagan J. M., 1973, CHEM HETEROCYCLIC CO, P141
[7] HUNIG S, 1960, LIEBIGS ANN CHEM, V636, P21
[8] EQUILIBRIUM-CONFIGURATIONS OF AZINES OF ESTERS
KEUS, D
WARKENTIN, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (19) : 3466 - 3469
[9] MARTIN GJ, 1972, PROGR NMR SPECTROSCO, V8, P163
[10] McCarty C. G., 1970, CHEM CARBON NITROGEN, P363

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