THIO AND NITROGEN ANALOGS OF ACRONYCINE

被引：1

作者：

GEEWANANDA, YA ^{[1
]}

GUNAWARDANA, P ^{[1
]}

CORDELL, GA ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1995年 / 18卷 / 03期

关键词：

ACRONYCINE; THIO ANALOGS; NITROGEN ANALOGS; CONFIGURATION ASSIGNMENTS;

D O I：

10.1007/BF02979195

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thio, thio acetyl, oxime, and several hydrazone and azine derivatives of the antitumor alkaloid acronycine (1) were prepared. NMR spectroscopy was used to study the configurations around the C=N double bond in these acronycine derivatives. In the hydrazones and azines of acronycine the N-N bond assumes a syn configuration to the G-OCH, group, while the N-O bond in the oxime and the N-N bond in noracronycine hydrazone and azines assumes an anti configuration.

引用

页码：195 / 202

页数：8

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