P53 AND KI-67 EXPRESSION IN PRENEOPLASTIC AND NEOPLASTIC LESIONS OF THE ORAL-MUCOSA

被引：55
|
作者：
GIROD, SC [1 ]
KRUEGER, G [1 ]
PAPE, HD [1 ]
机构：
[1] UNIV COLOGNE,INST PATHOL,W-5000 COLOGNE 41,GERMANY
来源：
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 1993年 / 22卷 / 05期
关键词：
CARCINOGENESIS; CANCER; ONCOLOGY; P53 TUMOR-SUPPRESSOR GENE;
D O I：
10.1016/S0901-5027(05)80517-X
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Some lesions of the oral mucosa such as leukoplakia and erythroplakia may develop into squamous cell carcinoma (SCC). At present, however, there is no method available to predict malignant transformation. It is known that the grade of dysplasia is related to the potential malignant development, but this is unreliable as the only indicator. In 64 hyperplastic lesions and 85 SCC of the oral mucosa, a correlation between the expression of the mutated tumor-suppressor gene p53 and the dysplasia of the lesions was found. Ki 67 was used as a proliferation marker. The results imply that expression of mutated p53 is an indicator for potential malignant development in benign lesions of the oral mucosa.
引用
收藏
页码：285 / 288
页数：4
相关论文
共 50 条
  • [1] P53 AND KI-67 EXPRESSION IN NEOPLASTIC AND PREPRENEOPLASTIC LESIONS OF THE ORAL-MUCOSA
    GIROD, S
    FISCHER, U
    KNUEFERMANN, R
    KRAEMER, C
    KRUGER, G
    FASEB JOURNAL, 1993, 7 (03): : A53 - A53
  • [2] Expression of Ki-67 and p53 in meningiomas
    Pavelin, S.
    Becic, K.
    Forempoher, G.
    Mrklic, I.
    Pogorelic, Z.
    Titlic, M.
    Andelinovic, S.
    NEOPLASMA, 2013, 60 (05) : 480 - 485
  • [3] Expression of P53 and Ki-67 correlated with oral epithelial dysplasia
    Freire Soares Marques, Y. M.
    Rodrigues Acay, R.
    Mendes Tribst, J. P.
    Clemente, A. E.
    Rodarte Carvalho, Y.
    ORAL DISEASES, 2014, 20 : 22 - 22
  • [4] P53 EXPRESSION IN THE CARCINOGENESIS IN THE ORAL-MUCOSA
    GIROD, SC
    KRAMER, C
    KNUFERMANN, R
    KRUEGER, GRF
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 56 (04) : 444 - 448
  • [5] Assessment of p53 and Ki-67 expression in snuff-induced lesions
    Wedenberg, C
    Jonsson, A
    Hirsch, JM
    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 1996, 34 (05): : 409 - 413
  • [6] Expression of P53 and a proliferative marker (Ki-67) in vulvar intraepithelial lesions
    Pinto, A
    Sun, D
    Crum, CP
    LABORATORY INVESTIGATION, 1999, 79 (01) : 122A - 122A
  • [7] Expression of p53 in preneoplastic and early neoplastic bronchial lesions
    Martin, B
    Verdebout, JM
    Mascaux, C
    Paesmans, M
    Rouas, G
    Verhest, A
    Ninane, V
    Sculier, JP
    ONCOLOGY REPORTS, 2002, 9 (02) : 223 - 229
  • [8] Heterogeneity of Ki-67 and p53 expression in glioblastomas
    Jakovlevs, A.
    Strumfa, I.
    Vanags, A.
    Gardovskis, J.
    VIRCHOWS ARCHIV, 2014, 465 : S252 - S253
  • [9] KI-67 AND P53 EXPRESSION IN ILEAL POUCHES
    Zurawski, Jakub
    Iwanik, Katarzyna
    Burchardt, Pawel
    Rzymski, Piotr
    Wiktorowicz, Krzysztof
    Ratajczak, Violetta
    Banasiewicz, Tomasz
    Grochowalski, Marcin
    Salwa-Zurawska, Wieslawa
    POLISH JOURNAL OF PATHOLOGY, 2012, 63 (02) : 126 - 130
  • [10] Immunohistochemistry Analysis of P53 and Ki-67 Proteins in Oral Lichen Planus and Normal Oral Mucosa
    Agha-Hosseini, F.
    Khalili, M.
    Rohani, B.
    IRANIAN JOURNAL OF PUBLIC HEALTH, 2009, 38 (02) : 37 - 43
12345