MHC CLASS-II ANTIGEN-PROCESSING - BIOLOGY OF INVARIANT CHAIN

被引：89

作者：

SANT, AJ ^{[1
]}

MILLER, J ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 01期

关键词：

D O I：

10.1016/0952-7915(94)90034-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The invariant chain (li) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of li or to specific regions within it. Thus, regulation of li synthesis, post-transcriptional events, and post-translational modification has the potential to dramatically modulate immune responses.

引用

页码：57 / 63

页数：7

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