A NEW MULTIENZYME SYSTEM FOR A ONE-POT SYNTHESIS OF SIALYL OLIGOSACCHARIDES - COMBINED USE OF BETA-GALACTOSIDASE AND ALPHA(2,6)-SIALYLTRANSFERASE COUPLED WITH REGENERATION INSITU OF CMP-SIALIC ACID

被引：59
作者：
HERRMANN, GF
ICHIKAWA, Y
WANDREY, C
GAETA, FCA
PAULSON, JC
WONG, CH
机构：
[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
[2] RES CTR JULICH, INST BIOTECHNOL, W-5170 JULICH, GERMANY
[3] CYTEL CORP, SAN DIEGO, CA 92121 USA
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期
关键词：
D O I：
10.1016/S0040-4039(00)93387-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An irreversible one-pot enzymatic synthesis of sialyl oligosaccharides has been achieved with a beta-galactosidase-catalyzed galactosylation of an acceptor followed by a sialyltransferase-catalyzed sialylation with regeneration in situ of CMP-sialic acid.
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收藏
页码：3091 / 3094
页数：4
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