CAFFEINATED AND DECAFFEINATED COFFEE EFFECTS ON PLASMA-LIPOPROTEIN CHOLESTEROL, APOLIPOPROTEINS, AND LIPASE ACTIVITY - A CONTROLLED, RANDOMIZED TRIAL

Coffee consumption has been associated with elevated plasma cholesterol. One hundred eighty-one men consumed a standard caffeinated coffee for 2 mo followed by randomization to continue caffeinated coffee (control), change to decaffeinated coffee or no coffee for 2 mo. Plasma low-density-lipoprotein (LDL) cholesterol and apolipoprotein B concentrations increased significantly (0.12 +/- 0.65 mmol/L, P < 0.025; 0.06 +/- 0.12 g/L, P < 0.0004, respectively) in the group that changed to decaffeinated coffee. In a subgroup (n = 51), postheparin lipoprotein lipase decreased significantly more (-270 mmol free fatty acids . L-1.h-1, P < 0.003) in the decaffeinated-coffee group. Resting heart rate and blood pressure did not change significantly. Change from caffeinated to decaffeinated coffee increased plasma LDL cholesterol and apolipoprotein B whereas discontinuation of caffeinated coffee revealed no change. This finding suggests that a coffee component other than caffeine is responsible for the LDL cholesterol, apolipoprotein B, and lipase activity changes reported in this investigation.