Dependence of nitrogen- and phosphorus-regulation of beta-lactam antibiotic production by Streptomyces clavuligerus on aeration level

被引：9
作者：
Fang, A
Demain, AL
机构：
[1] Fermentation Microbiology Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, MA
来源：
JOURNAL OF INDUSTRIAL MICROBIOLOGY | 1995年 / 15卷 / 05期
关键词：
nitrogen regulation; phosphorus regulation; cephamycin; secondary metabolism; antibiotics; Streptomyces clavuligerus;
D O I：
10.1007/BF01569965
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Interference with beta-lactam production in Streptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply, Under such a restriction, ammonium slightly stimulated and phosphate markedly stimulated beta-lactam antibiotic production. These are rare examples of 'regulation reversal' by an environmental modification.
引用
收藏
页码：407 / 410
页数：4
相关论文
共 11 条
[1]   INFLUENCE OF INORGANIC-PHOSPHATE AND ORGANIC BUFFERS ON CEPHALOSPORIN PRODUCTION BY STREPTOMYCES-CLAVULIGERUS [J].
AHARONOWITZ, Y ;
DEMAIN, AL .
ARCHIVES OF MICROBIOLOGY, 1977, 115 (02) :169-173
[2]   NITROGEN NUTRITION AND REGULATION OF CEPHALOSPORIN PRODUCTION IN STREPTOMYCES-CLAVULIGERUS [J].
AHARONOWITZ, Y ;
DEMAIN, AL .
CANADIAN JOURNAL OF MICROBIOLOGY, 1979, 25 (01) :61-67
[3]   INVOLVEMENT OF AERATION IN CARBON SOURCE REGULATION OF CEPHEM ANTIBIOTIC BIOSYNTHESIS IN STREPTOMYCES-CLAVULIGERUS [J].
BRANA, AF ;
HU, WS ;
DEMAIN, AL .
BIOTECHNOLOGY LETTERS, 1983, 5 (12) :791-794
[4]   AMMONIUM REPRESSION OF CEPHALOSPORIN PRODUCTION BY STREPTOMYCES-CLAVULIGERUS [J].
BRANA, AF ;
WOLFE, S ;
DEMAIN, AL .
CANADIAN JOURNAL OF MICROBIOLOGY, 1985, 31 (08) :736-743
[5]   A ROLE FOR ALANINE IN THE AMMONIUM REGULATION OF CEPHALOSPORIN BIOSYNTHESIS IN STREPTOMYCES-CLAVULIGERUS [J].
KASARENINI, S ;
DEMAIN, AL .
JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1994, 13 (04) :217-219
[6]   PHOSPHATE REPRESSION OF CEPHAMYCIN AND CLAVULANIC ACID PRODUCTION BY STREPTOMYCES-CLAVULIGERUS [J].
LEBRIHI, A ;
GERMAIN, P ;
LEFEBVRE, G .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1987, 26 (02) :130-135
[7]   REPRESSION AND INHIBITION OF CEPHALOSPORIN SYNTHETASES IN STREPTOMYCES-CLAVULIGERUS BY INORGANIC-PHOSPHATE [J].
LUBBE, C ;
WOLFE, S ;
DEMAIN, AL .
ARCHIVES OF MICROBIOLOGY, 1985, 140 (04) :317-320
[8]   OXYGEN DEREPRESSES DEACETOXYCEPHALOSPORIN-C SYNTHASE AND INCREASES THE CONVERSION OF PENICILLIN-N TO CEPHAMYCIN-C IN STREPTOMYCES-CLAVULIGERUS [J].
ROLLINS, MJ ;
JENSEN, SE ;
WOLFE, S ;
WESTLAKE, DWS .
ENZYME AND MICROBIAL TECHNOLOGY, 1990, 12 (01) :40-45
[9]   EFFECT OF DISSOLVED-OXYGEN CONTROL ON GROWTH AND ANTIBIOTIC PRODUCTION IN STREPTOMYCES-CLAVULIGERUS FERMENTATIONS [J].
YEGNESWARAN, PK ;
GRAY, MR ;
THOMPSON, BG .
BIOTECHNOLOGY PROGRESS, 1991, 7 (03) :246-250
[10]  
ZHANG J, 1989, FEMS MICROBIOL LETT, V48, P185
12