STRUCTURAL ELUCIDATION OF ACULEXIMYCIN .3. PLANAR STRUCTURE OF ACULEXIMYCIN, BELONGING TO A NEW CLASS OF MACROLIDE ANTIBIOTICS

被引：12

作者：

MURATA, H

SUZUKI, K

TABAYASHI, T

HATTORI, C

TAKADA, Y

HARADA, K

SUZUKI, M

IKEMOTO, T

SHIBUYA, T

HANEISHI, T

TORIKATA, A

ITEZONO, Y

NAKAYAMA, N

机构：

[1] MEIJO UNIV,FAC PHARM,NAGOYA,AICHI 468,JAPAN

[2] TEIKYO UNIV,SCH MED,ITABASHI KU,TOKYO 173,JAPAN

[3] SANKYO CO LTD,FERMENTAT RES LABS,TOKYO 140,JAPAN

[4] NIPPON ROCHE RES CTR,KAMAKURA,KANAGAWA 247,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 08期

关键词：

D O I：

10.7164/antibiotics.48.838

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The planar structure of aculeximycin (1) produced by Streptosporangium albidum has been determined by spectral methods and chemical degradations such as 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU)-methanol reaction, ozonolysis, and periodative oxidation. The antibiotic consists of a 30-membered polyhydroxy lactone ring, an alpha, beta-unsaturated ester group, an intramolecular hemiketal, an oligosaccharide (aculexitriose), a neutral sugar and an amino sugar. The structure of aculeximycin is closely related to those of sporaviridins produced by Streptosporangium viridogriseum. We consider that aculeximycin and sporaviridins belong to a new class of macrolide antibiotics, which is different from the polyol macrolides produced by Streptomyces.

引用

页码：838 / 849

页数：12

共 23 条

[1] ISOLATION OF NEOCOPIAMYCIN A FROM STREPTOMYCES-HYGROSCOPICUS VAR CRYSTALLOGENES, THE COPIAMYCIN SOURCE [J].