OPIOID ANTAGONIST ELIMINATES THE STRESS-INDUCED IMPAIRMENT OF LONG-TERM POTENTIATION (LTP)

被引：32
|
作者：
SHORS, TJ [1 ]
LEVINE, S [1 ]
THOMPSON, RF [1 ]
机构：
[1] STANFORD UNIV,DEPT PSYCHIAT,STANFORD,CA 94305
来源：
BRAIN RESEARCH | 1990年 / 506卷 / 02期
关键词：
Enkephalin; Hippocampus; Long-term potentiation; Naltrexone; Opioid peptide; Stress;
D O I：
10.1016/0006-8993(90)91270-Q
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rats (fn = 20) were injected with the opioid antagonist naltrexone and half were exposed to inescapable shock/restraint. Another 20 rats were injected with saline and half were exposed to shock. Neither saline nor naltrexone alone had any effect on hippocampal LTP. A large reduction in LTP was observed in saline rats exposed to shock, while normal LTP developed in the naltrexone rats exposed to shock. Thus, naltrexone eliminated the impairment, and thereby implicated endogenous opioids in the mechanism responsible for the stress-induced impairment of LTP. © 1990.
引用
收藏
页码：316 / 318
页数：3
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