SWARMING AND PATHOGENICITY OF PROTEUS-MIRABILIS IN THE URINARY-TRACT

被引：153
作者：
MOBLEY, HLT
BELAS, R
机构：
[1] UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21201
[2] UNIV MARYLAND,INST BIOTECHNOL,CTR MARINE BIOTECHNOL,BALTIMORE,MD 21202
来源：
TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 07期
关键词：
D O I：
10.1016/S0966-842X(00)88945-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proteus mirabilis is best known for its pattern of swarming differentiation on agar plates, as well as for its association with the development of renal stones in patients with urinary tract infection. Urease and flagella appear to contribute most significantly to virulence, with fimbriae playing a more subtle role, whereas hemolysin does not appear to contribute significantly to pathogenesis.
引用
收藏
页码：280 / 284
页数：5
相关论文
共 36 条
[1]   THE ROLE OF SWARM CELL-DIFFERENTIATION AND MULTICELLULAR MIGRATION IN THE UROPATHOGENICITY OF PROTEUS-MIRABILIS [J].
ALLISON, C ;
EMODY, L ;
COLEMAN, N ;
HUGHES, C .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (05) :1155-1158
[2]  
ALLISON C, 1992, MOL MICROBIOL, V6, P1583
[3]   CELL-DIFFERENTIATION OF PROTEUS-MIRABILIS IS INITIATED BY GLUTAMINE, A SPECIFIC CHEMOATTRACTANT FOR SWARMING CELLS [J].
ALLISON, C ;
LAI, HC ;
GYGI, D ;
HUGHES, C .
MOLECULAR MICROBIOLOGY, 1993, 8 (01) :53-60
[4]  
ALLISON C, 1991, SCI PROG, V75, P403
[5]   PROTEUS-MIRABILIS MR/P FIMBRIAL OPERON - GENETIC ORGANIZATION, NUCLEOTIDE-SEQUENCE, AND CONDITIONS FOR EXPRESSION [J].
BAHRANI, FK ;
MOBLEY, HLT .
JOURNAL OF BACTERIOLOGY, 1994, 176 (11) :3412-3419
[6]   CONSTRUCTION OF AN MR/P FIMBRIAL MUTANT OF PROTEUS-MIRABILIS - ROLE IN VIRULENCE IN A MOUSE MODEL OF ASCENDING URINARY-TRACT INFECTION [J].
BAHRANI, FK ;
MASSAD, G ;
LOCKATELL, CV ;
JOHNSON, DE ;
RUSSELL, RG ;
WARREN, JW ;
MOBLEY, HLT .
INFECTION AND IMMUNITY, 1994, 62 (08) :3363-3371
[7]   PROTEUS-MIRABILIS FIMBRIAE - N-TERMINAL AMINO-ACID-SEQUENCE OF A MAJOR FIMBRIAL SUBUNIT AND NUCLEOTIDE-SEQUENCES OF THE GENES FROM 2 STRAINS [J].
BAHRANI, FK ;
COOK, S ;
HULL, RA ;
MASSAD, G ;
MOBLEY, HLT .
INFECTION AND IMMUNITY, 1993, 61 (03) :884-891
[8]   GENETIC-ANALYSIS OF PROTEUS-MIRABILIS MUTANTS DEFECTIVE IN SWARMER CELL ELONGATION [J].
BELAS, R ;
GOLDMAN, M ;
ASHLIMAN, K .
JOURNAL OF BACTERIOLOGY, 1995, 177 (03) :823-828
[9]   EXPRESSION OF MULTIPLE FLAGELLIN-ENCODING GENES OF PROTEUS-MIRABILIS [J].
BELAS, R .
JOURNAL OF BACTERIOLOGY, 1994, 176 (23) :7169-7181
[10]   PROTEUS-MIRABILIS MUTANTS DEFECTIVE IN SWARMER CELL-DIFFERENTIATION AND MULTICELLULAR BEHAVIOR [J].
BELAS, R ;
ERSKINE, D ;
FLAHERTY, D .
JOURNAL OF BACTERIOLOGY, 1991, 173 (19) :6279-6288
1234