RP 67580, A SELECTIVE ANTAGONIST OF NEUROKININ-1 RECEPTORS, MODIFIES SOME OF THE NALOXONE-PRECIPITATED MORPHINE-WITHDRAWAL SIGNS IN RATS

被引：37

作者：

MALDONADO, R

GIRDLESTONE, D

ROQUES, BP

机构：

[1] UNIV PARIS 05, FAC SCI PHARMACEUT & BIOL,INSERM,U266, UNITE PHARMACOCHIM MOLEC, F-75270 PARIS 06, FRANCE

[2] RHONE POULENC RORER, CTR RECH VITRY ALFORTVILLE, Vitry Sur Seine, FRANCE

来源：

NEUROSCIENCE LETTERS | 1993年 / 156卷 / 1-2期

关键词：

SUBSTANCE-P; NK1; RECEPTOR; RP; 67580; MORPHINE-WITHDRAWAL; ABSTINENCE; NALOXONE;

D O I：

10.1016/0304-3940(93)90457-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to clarify the participation of substance P in the expression of opiate withdrawal, we have investigated the effects induced by the new selective neurokinin-1 antagonist RP 67580 on naloxone-induced morphine withdrawal syndrome in rats, Intracerebroventricular administration of RP 67580 elicited a decrease in 7 of the 13 withdrawal signs evaluated. Mastication, salivation and signs related to the motor component of withdrawal (jumping, rearing and locomotor activity) were particularly reduced. One sign, wet dog shakes, was increased, but it was also enhanced by the inactive enantiomer RP 68651. Our results indicate that blockade of NK1 receptors induces a decrease in the expression of naloxone-precipitated morphine abstinence in rats, and support the participation of substance P in the opiate withdrawal response.

引用

页码：135 / 140

页数：6

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