DEMONSTRATION OF A CELL-WALL ANTIGEN CROSS-REACTING WITH CRYPTOCOCCAL POLYSACCHARIDE IN EXPERIMENTAL DISSEMINATED TRICHOSPORONOSIS

被引：44
作者：
MELCHER, GP
REED, KD
RINALDI, MG
LEE, JW
PIZZO, PA
WALSH, TJ
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284
[2] NCI,PEDIAT BRANCH,INFECT DIS SECT,BETHESDA,MD 20892
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 1991年 / 29卷 / 01期
关键词：
D O I：
10.1128/JCM.29.1.192-196.1991
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Patients with disseminated infections caused by Trichosporon beigelii have a circulating antigen that cross-reacts with the polysaccharide capsule of Cryptococcus neoformans. We studied the localization of this antigen by immunoelectron microscopy in a rabbit model of experimental disseminated trichosporonosis. Deparaffinized lung sections were examined by using a murine monoclonal anti-cryptococcal polysaccharide antibody and colloidal gold particles coated with goat antibody to murine immunoglobulin G. Antigen that cross-reacted with the monoclonal antibody was observed in the T. beigelii cell wall and in a fibrillar matrix extending from the cell wall.
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页码：192 / 196
页数：5
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