PHENETHYL ALCOHOL DISORDERS PHOSPHOLIPID ACYL CHAINS AND PROMOTES TRANSLOCATION OF THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C ACROSS A LIPID BILAYER

被引：11

作者：

JORDI, W ^{[1
]}

NIBBELING, R ^{[1
]}

DEKRUIJFF, B ^{[1
]}

机构：

[1] STATE UNIV UTRECHT,INST MOLEC BIOL & MED BIOTECHNOL,3584 CH UTRECHT,NETHERLANDS

来源：

FEBS LETTERS | 1990年 / 261卷 / 01期

关键词：

Apocytochrome c; Deuterium nuclear magnetic resonance; Mitochondrial protein import; Phenethyl alcohol; Protein-lipid interactions;

D O I：

10.1016/0014-5793(90)80635-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of phenethyl alcohol with model membranes and its effect on translocation of the chemically prepared mitochondrial precursor protein apocytochrome c across a lipid bilayer was studied. Phenethyl alcohol efficiently penetrates into monolayers and causes acyl chain disordering judged from deuterium nuclear magnetic resonance measurements with specific acyl chain-deuterated phospholipids. Translocation of apocytochrome c across a phospoholipid bilayer was stimulated on addition of phenethyl alcohol indicating that the efficiency of translocation of this precursor protein is enhanced due to a disorder of the acyl chain region of the bilayer. © 1990.

引用

页码：55 / 58

页数：4

共 8 条

[1] STUDIES ON THE LIPID DEPENDENCY AND MECHANISM OF THE TRANSLOCATION OF THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C ACROSS MODEL MEMBRANES
RIETVELD, A
JORDI, W
DEKRUIJFF, B
JOURNAL OF BIOLOGICAL CHEMISTRY, 1986, 261 (08) : 3846 - 3856
[2] THE IMPORTANCE OF THE AMINO TERMINUS OF THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C FOR TRANSLOCATION ACROSS MODEL MEMBRANES
JORDI, W
ZHOU, LX
PILON, M
DEMEL, RA
DEKRUIJFF, B
JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (04) : 2292 - 2301
[3] IS THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C ABLE TO PASS A LIPID BARRIER
RIETVELD, A
DEKRUIJFF, B
JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, 259 (11) : 6704 - 6707
[4] INVESTIGATIONS ON THE INSERTION OF THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C INTO MODEL MEMBRANES
RIETVELD, A
PONJEE, GAE
SCHIFFERS, P
JORDI, W
VANDECOOLWIJK, PJFM
DEMEL, RA
MARSH, D
DEKRUIJFF, B
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 818 (03) : 398 - 409
[5] APOCYTOCHROME-C - AN EXCEPTIONAL MITOCHONDRIAL PRECURSOR PROTEIN USING AN EXCEPTIONAL IMPORT PATHWAY
STUART, RA
NEUPERT, W
BIOCHIMIE, 1990, 72 (2-3) : 115 - 121
[6] INTERACTIONS OF MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C WITH PHOSPHATIDYLSERINE IN MODEL MEMBRANES - A MONOLAYER STUDY
PILON, M
JORDI, W
DEKRUIJFF, B
DEMEL, RA
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 902 (02) : 207 - 216
[7] THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C STRONGLY INFLUENCES THE ORDER OF THE HEADGROUP AND ACYL CHAINS OF PHOSPHATIDYLSERINE DISPERSIONS - A H-2 AND P-31 NMR-STUDY
JORDI, W
DEKROON, AIPM
KILLIAN, JA
DEKRUIJFF, B
BIOCHEMISTRY, 1990, 29 (09) : 2312 - 2321
[8] SPECIFICITY OF THE INTERACTION OF AMINO-TERMINAL AND CARBOXY-TERMINAL FRAGMENTS OF THE MITOCHONDRIAL PRECURSOR PROTEIN APOCYTOCHROME-C WITH NEGATIVELY CHARGED PHOSPHOLIPIDS - A SPIN-LABEL ELECTRON-SPIN RESONANCE STUDY
JORDI, W
DEKRUIJFF, B
MARSH, D
BIOCHEMISTRY, 1989, 28 (23) : 8998 - 9005

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