Cell Signals Influencing Hepatic Fibrosis

被引：57
作者：
Cong, Min [1 ]
Iwaisako, Keiko [1 ]
Jiang, Chunyan [1 ]
Kisseleva, Tatiana [1 ]
机构：
[1] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
来源：
INTERNATIONAL JOURNAL OF HEPATOLOGY | 2012年 / 2012卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1155/2012/158547
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver fibrosis is the result of the entire organism responding to a chronic injury. Every cell type in the liver contributes to the fibrosis. This paper first discusses key intracellular signaling pathways that are induced during liver fibrosis. The paper then examines the effects of these signaling pathways on the major cell types in the liver. This will provide insights into the molecular pathophysiology of liver fibrosis and should identify therapeutic targets.
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页数：18
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