Background: A suboptimal degree of attention has focused on the detection and management of coronary artery disease (CAD) in women until recently. We sought out to study the anatomy of coronary arteries in women by the means of coronary angiography in comparison to men. The results of percutaneous coronary intervention (PCI) and in hospital outcomes were studied and compared to men. Methods: The study included 488 female and 492 male patients with chronic stable angina undergoing coronary angiography PCI taken consecutively. The angiographic results, interventional details and procedural success, and related complications were collected and statistically analyzed. Results: Female patients had similar coronary risk factors with higher incidence of diabetes mellitus and lower history of smoking. The likelihood of non-atherosclerotic affliction of the coronaries was 47 A in women vs. 25.5 A in men (P < 0.001). The prevalence of multivessel affliction and more complex lesions were significantly lower in the female patients compared to their male counterparts (P < 0.001). Female patients had lower rate of PCI procedures and lower number of stents implanted (P < 0.001) including drug eluting stents. The success rates were similar in both the sexes, with relatively higher complication rate in the female group. Conclusion: Egyptian women have generally similar risk profile to male patients with CAD and tend to receive less aggressive therapy. They showed less severe coronary atherosclerosis than men and potentially have lower PCI procedures with similar acute success rates and relatively higher procedure-related complications. (C) 2011 Egyptian Society of Cardiology. Production and hosting by Elsevier B.V. All rights reserved.