Because the neurosciences affect many areas of society and culture, they receive much public attention. Brain research and other focuses of neuroscience are regularly featured in the mass media, calling on neuroscientists to serve as sources. Based on 30 semi-structured interviews with neuroscientists in the United States and Germany, this article analyzes neuroscientists' motivations to interact with journalists, their perception of problems with the media reporting of neuroscience and media contacts, and the strategies they apply in order to gain some control over the coverage. Results show that most neuroscientists perceive benefits of media coverage and are willing to cooperate with journalists and conform to their expectations, but only to a certain degree. Neuroscientists perceive problems regarding the quality of coverage, risks related to public visibility and negative consequences of being distracted from research and scientific publication because of the time demands of media interactions. The scientists discussed several strategies to improve this perceived cost-benefit ratio.