SYNTHESIS OF [C-14(2)] SDZ FOX-988, A HYPOGLYCEMIC AGENT

被引：2

作者：

SUNAY, UB ^{[1
]}

TALBOT, K ^{[1
]}

PRASAD, K ^{[1
]}

LEE, G ^{[1
]}

JONES, L ^{[1
]}

机构：

[1] SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT CHEM RES & DEV,PROC RES & DEV LABS,HANOVER,NJ 07936

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1995年 / 36卷 / 06期

关键词：

C-14; NON-INSULIN DEPENDENT DIABETES MELLITUS; N-OXYIMIDIC ACID DERIVATIVES;

D O I：

10.1002/jlcr.2580360604

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

4-[2,2-Dimethyl-1-oxopropyl-1-[C-14]-4-[2,2-dimethyl-1-oxopropyl-1-[C-14]-phenyl(methoxyimino)-benzoic acid, methyl ester, [C-14(2)] SDZ FOX 988, doubly labelled in the two keto carbons, was prepared from 4-bromotoluene in four steps. The final condensation featured a novel method for preparation of N-oxyimidic acid derivatives.

引用

页码：529 / 535

页数：7

共 8 条

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